portal 2 pump station gamma control room

Portal 2 pump station gamma control room series#

The reaction appears to be complement dependent. Patients exhibiting this response are believed to have become immunized during multiple pregnancies, by means of repeated blood transfusions while awaiting renal transplantation, or by previous renal transplants. Since that report, clinical and experimental evidence of antibody mediated rejection of renal allografts has been described by Williams, Starzl, Clark, Najarian and others( 11– 17). The microscopic picture of these grafts revealed cortical necrosis caused by microthrombi in the glomeruli and small arterioles similar to the picture produced by the Schwartzman reaction. ( 10) described hyperacute rejection mediated by IgG, IgA, and IgM antibodies to renal allografts in 2 patients.

While the central role of small lymphocytes in chronic rejection has been known a long time, the more dramatic effect of preformed circulating antibodies in causing hyperacute rejection has been recognized only recently. These experiments have been prompted by the urgent need for a method for removal of antibodies in previously immunized patients to allow kidney transplantation.

Portal 2 pump station gamma control room series#

In the present series of experiments it has been applied to the experimental modification of the rejection reaction of pig kidney's xenografts in dogs. It employs the forced-flow electrophoretic technique( 1, 2, 5, 6), which has been recently employed for the preparation of anti-lymphocytic globulins from horses in vivo( 7) and in vitro( 8, 9). The general procedure is similar to that employed with artificial kidneys and, more specifically, with blood electrodialysis( 4). Selective plasmapheresis is a technique whereby a gamma globulin rich fraction is electrophoretically separated from heparinized whole blood maintained in extracorporeal circulation( 1– 3).